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Physicians and other health care providers can use these guidelines to assist in prevention and treatment of STIs. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease 3) alternative treatment options for bacterial vaginosis 4) management of Mycoplasma genitalium 5) human papillomavirus vaccine recommendations and counseling messages 6) expanded risk factors for syphilis testing among pregnant women 7) one-time testing for hepatitis C infection 8) evaluation of men who have sex with men after sexual assault and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. The information in this report updates the 2015 guidelines. These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11–14, 2019.

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